Relevance and Impact
Relevance to the objectives of the Life Sciences,
Genomics and Biotechnology for Health
In the work programme 'Integration and strengthening the European Research area' under priority 1: Life Sciences, Genomics and Biotechnology for Health, the focus of this Integrated Project as presented in the call 'LSH-2003-1.1.5-5, DNA damage and repair mechanism in health and disease', has been defined as using a multidisciplinary approach to decipher the core molecular mechanisms of DNA damage and repair.
The realisation of the importance of preservation of genetic integrity is one of the major developments within the field of biomedical genetics over the last decade. Alteration of genetic information has major impacts not only on carcinogenesis, but also on ageing and other aspects of human health. Understanding the detailed mechanisms through which genome integrity is maintained, including DNA damage repair mechanisms, is thus of pivotal importance for improvement of numerous quality of life issues. Thus, this project intends to unravel the mechanisms that safeguard the integrity of the genome, using an integral approach ranging form molecules to patients.
The impact and benefits from this integrated project extend beyond the participating groups because both at the national and international level, the participants of this consortium are involved in collaborative networks that join research groups outside of this consortium with relevant and complementary research interests. These collaborative efforts are often formalised by common project funding and include research activities carried out by public organisations such as universities, academic hospitals, and governmental institutions, but also companies. In addition, individual members of the participating laboratories are members of advisory boards of national and international governmental and non-governmental organisations through which they contribute to making informed judgements on human health risks due to environmental exposure.
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